Relationship between Rate of Elimination of Tubocurarine and Rate of Decline of Its Pharmacological Activity.

The design of rational dosage schedules of tubocurarine to obtain sustained muscular relaxation has recently been described by Ryan (1964). His paper dealt primarily with the time course of tubocurarine concentration or amount in the body; it is intended here to consider the time course of tubocurarine activity. Let it be assumed that the intensity of pharmacological activity of tubocurarine is related linearly to the logarithm of the body drug content (dose). This is a common finding with most drugs and applies over a considerable range of pharmacological activity. In mathematical terms